Fetal programming and epigenetic mechanisms in arterial hypertension
نویسندگان
چکیده
منابع مشابه
Fetal programming and epigenetic mechanisms in arterial hypertension.
PURPOSE OF REVIEW To provide an overview of available evidence of the potential role of epigenetics in the pathogenesis of hypertension and vascular dysfunction. RECENT FINDINGS Arterial hypertension is a highly heritable condition. Surprisingly, however, genetic variants only explain a tiny fraction of the phenotypic variation and the term 'missing heritability' has been coined to describe t...
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Events that occur in the early fetal environment have been linked to long-term health and lifespan consequences in the adult. Intrauterine growth restriction (IUGR), which may occur as a result of nutrient insufficiency, exposure to hormones, or disruptions in placental structure or function, may induce the fetus to alter its developmental program in order to adapt to the new conditions. IUGR m...
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Essential hypertension remains poorly understood, despite the enormous efforts of research, which brought understanding of certain physiopathological and treat ment mechanisms. New insights have emerged from recent data showing that environmental insults during (in vitro) fertilisation, foetal, perinatal and childhood periods may lead to vascular dysfunction and hyper tension later in life (t...
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ژورنال
عنوان ژورنال: Current Opinion in Cardiology
سال: 2015
ISSN: 0268-4705
DOI: 10.1097/hco.0000000000000192